SkinEthic RHE 2.0 / Reconstructed Human Epidermis

Name

SkinEthic^TM RHE 2.0 / Reconstructed Human Epidermis

Description

SkinEthic^TMRHE 2.0 is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. Improved production so every single process is guaranteed devoid of any animal constituents and tissue production now guaranteed devoid of any animal components with traceability of all ingredients.

This model exists at different stages of maturity.

This model is histologically similar to in vivo human epidermis.

Specific markers

Differentiation markers:

Filaggrin (See picture)
Involucrin
Loricrin (See picture)
Transglutaminase
Keratin 10 (See picture)
Keratin 5
CD44 (See picture)
Presence of different epidermal classes of lipids comprising ceramides

Dermal-Epidermal junction markers

Type IV collagen
Laminin V
Alpha6Beta4-integrin
BP antigen

Proliferation markers

Ki67 (See picture)

Applications

Format

0.5 cm² (See picture)
4 cm² (See picture)
HTS 24-well plate 0.33 cm² (See picture)
HTS 96-well plate 0.11 cm² (See picture)

Cell Migration Model

Description

Cell Migration Models (CMM) are epidermal models on an innovative insert.

Epidermal or mucosal reconstructed on this insert are histologically similar to in vivo human epidermis and mucosa.