Vaginal irritation

Vaginal irritation


The vaginal epithelium model is particularly useful to conduct research project on female hygiene. For example it can be used to determine vaginal tolerance risk assessment or local medecine development.

 Moreover, our vaginal epithelium is also a good model for bacterial adhesion research projects. 


Example of applications:

  • Vaginal irritation
  • Vaginal medicine development
  • Vaginal candidosis understanding



   SkinEthicTM HVE




Integrated in vitro vaginal safety approach for bath and body wash products utilizing SkinEthic Human Vaginal Epithelium (HVE) model.

Vinayak S, Alonso A, Bertino B, Costin GE, de Brugerolle de Fraissinette A, Orak D, Inglis H, Kazmi P, Raabe H, Re T. SOT 2010.

Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis. Naglik JR et al. Microbiology, 154, 3266-3280, 2008.
Candida albicans-secreted aspartic proteinases (Sap) modify the epithelial cytokine response in an in vitro model of vaginal candidiasis. Schaller M, Korting HC, Borelli C, Hamm G, Hube B. Infect Immun 73 (5): 2758-2765, 2005.
The secreted aspartyl proteinases sap1 and sap2 cause tissue damage in an in vitro model using vaginal candidiasis using reconstituted human vaginal epithelium. Schaller M, Bein M, Korting HC, Baur S, Hamm G, Monod M, Beinhauer S and  Hube B. Infection and Immunology, 71, 6, 3227-3234, 2003.