SkinEthic RHE / Human Epidermis

NAME: SkinEthicTM RHE / Reconstructed Human Epidermis

 

  

The in vitro Reconstructed Human Epidermis consists of normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium.

This model is histologically similar to in vivo human epidermis.

SPECIFIC MARKERS

APPLICATIONS 
Differentiation markers:
  • Filaggrin
  • Involucrin
  • Loricrin
  • Keratin 10
  • Keratin 5
  • Presence of different epidermal classes of lipids comprising ceramides
 Skin Irritation
 Skin Corrosion
Phototoxicity
DNA damage

Dermal-Epidermal junction markers

  • Type IV collagen
  • Laminin V
  • Alpha6Beta4-integrin
  • BP antigen
 Bacterial adhesion
Omics

 Proliferation markers

  • Ki67
 Permeability

 FORMAT

 
  • 0.5 cm²
  • 4 cm²
  • HTS 24-well plate 0.33 cm²
  • HTS 96-well plate 0.11 cm²