The SkinEthic RHPE model presents a histological morphology comparable to the in vivo human tissue, consisting in the presence of a multi-layered, stratified and pigmented epidermis. Melanocytes are localized in the basal cell layer interspersed with basal cell keratinocytes. Moreover, melanin is distributed in the basal layer melanocytes and in upper layer keratinocytes similarly to that seen in normal human skin, reflecting its transfer into surrounding proliferating keratinocytes.
SkinEthic RHPE model exhibits a homogeneous tanning demonstrating the functionality of the epidermal melanin unit in vitro and that the obtained phototype is determined by the melanocyte phototype, i.e. the rate of constitutive melanin synthesis.