SkinEthic RHE / Human Epidermis
Name
SkinEthicTM RHE / Reconstructed Human Epidermis
Description
SkinEthicTM RHE is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. This model exists at different stages of maturity.
This model is histologically similar to in vivo human epidermis.
Specific markers
Differentiation markers:
- Filaggrin
- Involucrin
- Loricrin
- Keratin 10
- Keratin 5
- Presence of different epidermal classes of lipids comprising ceramides
Dermal-Epidermal junction markers
- Type IV collagen
- Laminin V
- Alpha6Beta4-integrin
- BP antigen
Proliferation markers
in vitro
Cell Migration Model
Description
Cell Migration Models (CMM) are epidermal models on an innovative insert.
Epidermal or mucosal reconstructed on this insert are histologically similar to in vivo human epidermis and mucosa.