SkinEthic RHE / Human Epidermis

Name

SkinEthicTM RHE / Reconstructed Human Epidermis

Description

SkinEthicTM RHE is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. This model exists at different stages of maturity.

This model is histologically similar to in vivo human epidermis.

Specific markers

Differentiation markers:

  • Filaggrin
  • Involucrin
  • Loricrin
  • Keratin 10
  • Keratin 5
  • Presence of different epidermal classes of lipids comprising ceramides

Dermal-Epidermal junction markers

  • Type IV collagen
  • Laminin V
  • Alpha6Beta4-integrin
  • BP antigen

Proliferation markers

  • Ki67
RHE in Vitro
in vitro

Applications

Format

Cell Migration Model

Cell Migration Model

Description

Cell Migration Models (CMM) are epidermal models on an innovative insert.

 

Epidermal or mucosal reconstructed on this insert are histologically similar to in vivo human epidermis and mucosa.