SkinEthic RHE / Human Epidermis


SkinEthicTM RHE / Reconstructed Human Epidermis


SkinEthicTM RHE is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. This model exists at different stages of maturity.

This model is histologically similar to in vivo human epidermis.

Specific markers

Differentiation markers:

  • Filaggrin
  • Involucrin
  • Loricrin
  • Keratin 10
  • Keratin 5
  • Presence of different epidermal classes of lipids comprising ceramides

Dermal-Epidermal junction markers

  • Type IV collagen
  • Laminin V
  • Alpha6Beta4-integrin
  • BP antigen

Proliferation markers

  • Ki67
RHE in Vitro
in vitro