SkinEthic RHE / Human Epidermis
Name
SkinEthicTM RHE / Reconstructed Human Epidermis
Description
SkinEthicTM RHE is an in vitro reconstructed human epidermis from normal human keratinocytes cultured on an inert polycarbonate filter at the air-liquid interface, in a chemically defined medium. This model exists at different stages of maturity.
This model is histologically similar to in vivo human epidermis.
Specific markers
Differentiation markers:
- Filaggrin
- Involucrin
- Loricrin
- Keratin 10
- Keratin 5
- Presence of different epidermal classes of lipids comprising ceramides
Dermal-Epidermal junction markers
- Type IV collagen
- Laminin V
- Alpha6Beta4-integrin
- BP antigen
Proliferation markers
in vitro